Dietary Fat, Eicosanoids and Breast Cancer Risk
Abstract
This project is a traineeship for the Primary Investigator's doctoral training and encompasses a training and research plan in breast cancer research. The PI is being mentored by three prominent researchers with expertise in multiple areas of breast cancer research: coordination and execution a highly controlled breast cancer prevention feeding trial by Susan Raatz, PhD, R.D.; exposure to clinical oncology and clinical application of the results of the proposed research project by Douglas Yee, M.D.; and laboratory analysis of sex hormones and dietary prevention of breast cancer by Mindy Kurzer, PhD. All required course work for the PI was completed in December of 2007. The PI passed the oral preliminary examination and the written preliminary examinations prior to September 15, 2007. The purpose of the proposed dietary intervention trial is to determine the effects of type and amount of dietary fat on sex hormone metabolism, eicosanoid balance, and breast cancer risk in postmenopausal women. The study objectives are to: 1) evaluate the effects of total fat and omega-3 fatty acid intake on plasma and urinary sex hormone and urinary eicosanoid levels; 2) determine the relationships among plasma fatty acids, urinary prostaglandin E2, plasma and urinary sex hormones, and plasma insulin, insulin-like growth factor, and insulin-like growth factor binding proteins. The controlled feeding trial portion of the study is currently proceeding. To date 142 subjects have been screened via telephone, 32 subjects have been screened in the clinic, and 24 subjects have been enrolled in the study. Sixteen subjects have completed all parts of the feeding trial. Plasma sex hormones were analyzed by radio-immuno assay for the first 10 subjects to complete the trial. Preliminary data from this analysis was used to generated two abstracts that were presented at the DOD 2008 Era of Hope meeting. No manuscripts have been generated to date.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2008
- Accession Number
- ADA502561
Entities
People
- Lindsay Orr
Organizations
- University of Minnesota