Prediction of Aggressive Human Prostate Cancer by Cathepsin B
Abstract
I received approval of the DOD-HSRRB in April, 2005 and began the study shortly after receiving approval. We are enclosing copies of published and accepted papers in the Anticancer Research. These papers address parts of both Specific Aims outlined in the project. I submitted an abstract of our accepted paper, "Cathepsin B Expression Indicates that Prostate Cancer is Similar in African-American and Caucasian Men" to the Department of Defense Prostate cancer research program meeting: Innovative Minds in Prostate Cancer Today (IMPACT). Our abstract was selected and accepted for presentation on September 5-6 meetings in Atlanta, GA. This is significant achievement for our work that started in April 2005. Our paper, "Heterogeneity of Cathepsin B and Stefin A Expression in Gleason Pattern 3+3 (score 6) Prostate Cancer Needle Biopsies" was published in Anticancer Research 27: 1407-1414, 2007. We showed that small foci of Gleason pattern 3+3 (histological score 6) tumors in needle biopsies have heterogeneous cathepsin B and stefin A immunostaining. We have shown that score 6 tumors are heterogeneous and some of the tumors had micrometastases. We have suggested that stratification of these tumors by cathepsin B and stefin A in relation to clinical data may assist in identification of aggressive cancer and treatment selection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2008
- Accession Number
- ADA502574
Entities
People
- Akhouri A. Sinha
Organizations
- University of Minnesota