A Harmonized Physiologically Based Pharmacokinetic Model for Nonane as a Component of Jet Fuel
Abstract
JP-8 is a complex mixture of hundreds of components including straight and branched chain alkanes, cycloalkanes, diaromatics and naphthalenes. Inhalation and dermal are the most prevalent routes of exposure. Occupations of interest include aircraft fuel tank and exhaust workers. To assess potential health effects of such exposures, it is useful to predict target site dosimetry of JP-8 components. A first step in this process is to develop a physiologically based pharmacokinetic (PBPK) model for representative mixture components. Single-chemical models can then be "harmonized" (same physiological structure) and combined into a composite-mixture model. A harmonized model structure should be complex enough to take into account all important physiological processes undergone by any component in an integrated fashion; the same physiological structure must underlie each of the individual models. The initial framework for such a model is developed here on the basis of observed kinetic behavior of nonane, an aliphatic JP-8 component. Nonane is highly lipophilic and distributes preferentially in brain tissue.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 16, 2007
- Accession Number
- ADA502610
Entities
People
- Elaine A. Merrill
- Peter J. Robinson