Androgen, Estrogen, and the Bone Marrow Microenvironment

Abstract

In this project we plan to analyze androgen- and estrogen-responsive gene expression in the bone marrow. We plan to work to: determine if castration-induced gene expression changes in mouse bone marrow are caused by the deficiency of testosterone or estrogen; analyze androgen and estrogen-sensitive cytokine and gene expression changes in human bone marrow transplanted into NOD/SCID mice, and; examine androgen- and estrogen-sensitive gene expression in the bone marrow of patients with low and high circulating testosterone levels. This research project was delayed as a result of second-level review required by the US Army Medical Research Material Command's Human Subjects Research Review Board (HSRRB). Final approval from the HSRRB was received on November 21, 2006. We are now organizing the animal work and obtaining human samples of bone marrow from patients with prostate cancer for analysis.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2008
Accession Number
ADA502772

Entities

People

  • Beatrice S Knudsen

Organizations

  • Fred Hutchinson Cancer Center

Tags

DTIC Thesaurus Topics

  • Androgens
  • Biomedical Research
  • Blood
  • Bone Marrow
  • Castration
  • Cell Line
  • Cells
  • Chemistry
  • Cytokines
  • Gene Expression
  • Materials
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Stromal Cells
  • Testosterone

Readers

  • Breast cancer cell signaling and growth regulation.
  • Clinical Trial Research.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology