Interactions between Vitamin D and Breast Cancer
Abstract
Thus far we have recruited 14 breast cancer (BCa) patients. The women were stratified according to their vitamin D status: 9 have normal circulating levels of vitamin D (>30 ng/mL), 3 have insufficient levels of vitamin D (1729 ng/mL) and 2 have deficient levels (<16 ng/mL). We have intervened in the neoadjuvant period between biopsy and surgery and treated the insufficient patients with 2000 IU of vitamin D and the deficient patients with 4000 IU of vitamin D. We will analyze their biopsy samples (preintervention) and compare results with the surgical specimens (postintervention) to determine whether dietary vitamin D supplements can regulate the gene expression profile in the BCa. Further, we will determine whether vitamin D deficiency is associated with a poor prognosis profile and whether vitamin D intervention converts the profile toward a more normal profile of gene expression, perhaps representing a better prognosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2008
- Accession Number
- ADA502825
Entities
People
- David Feldman
Organizations
- Stanford University