Effects of Radiation on Proteasome Function in Prostate Cancer Cells

Abstract

The proposed research is based on our observation that the 26S proteasome is a direct target of radiation. We initially planned experiments to investigate the association and release of PIPs from the 26S proteasome as well as studies more focused on the structural changes of the proteasome in response to radiation. We also wanted to investigate how the 26S is regulated by radiation at the transcriptional and posttranslational level and we are addressing these aims using powerful proteomic tools.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2009
Accession Number
ADA502828

Entities

People

  • Frank Pajonk

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Gene Expression
  • Mass Spectrometry
  • Neoplasms
  • Oncology
  • Peptides
  • Polymeric Films
  • Proteins
  • Proteomics
  • Stem Cells

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology and Biomarker-Based Cancer Detection.
  • Systems Analysis and Design

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech