Investigating the Role of TBX2 in the Inhibition of Senescence in Prostate Cancer

Abstract

The aim of this project is to dissect the role of Tbx2 in prostate cancer progression. In this period of the study, we found that blocking endogenous Tbx2 expression in PC3 cells by using a dominant negative construct (PC3-Tbx2 DN) reduced the osteolytic burden of these cells when placed in the bone microenvironment as compared to control PC3 cells. This finding suggests that Tbx2 plays a role in the growth of prostate cancer cells in the bone. Further, to study the role of Tbx2 in bone metastasis, we created a mouse model overexpressing hepsin and myc in the mouse prostate. This bigenic model develops adenocarcinoma earlier than the myc alone mouse and at higher ages develops higher grade adenocarcinoma.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2009
Accession Number
ADA502941

Entities

People

  • Srinivas Nandana

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Adenocarcinoma
  • Androgen Receptors
  • Androgens
  • Biological Aging
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Department Of Defense
  • Growth Factors
  • Membranes
  • Metastasis
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Tissues
  • X Rays

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).