Ets2 Contributions of the Tumor Microenvironment in Breast Cancer Metastasis
Abstract
According to the American Cancer Society, the chance being diagnosed with invasive breast cancer is about 1 in 8 and the chance of dying from breast cancer is about 1 in 33. The recent trend toward a decrease in breast cancer mortality rate is largely due to increased diagnosis of early stage disease, while therapeutic options for advanced stage breast carcinomas are still fairly limited. Currently, metastasis is the most lethal complication of breast cancer and therapies to prevent the spread of breast cancer cells do not exist (1). Little is known about the genetic contributions of metastasis and the role of the microenvironment at the metastatic site. Therefore, in order to find therapeutic drugs to prevent metastasis it is critical to understand the genetic cross talk between different compartments of the metastatic microenvironment which support their growth.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2009
- Accession Number
- ADA502943
Entities
People
- Jillian L. Werbeck
Organizations
- Ohio State University