Carcinogenicity of Embedded Tungsten Alloys in Mice
Abstract
A variety of unique metal mixtures have entered the military arsenals of many countries in recent years. One such material is the tungsten alloys, which have been proposed as replacements for depleted uranium (DU) in armor-penetrating munitions. As a result, opportunities for exposure are increasingly likely. This leads to questions, similar to those originally surrounding DU, as to the health effects of exposure to the tungsten alloys, especially for embedded fragment exposures. The Armed Forces Radiobiology Research Institute (AFRRI) recently performed research that showed one of the militarily promising tungsten alloys to be a potent carcinogen when implanted in rats. The need to confirm the carcinogenicity of such alloys in another rodent species is an important second step required in biological as well as regulatory terms to better assess the cancer risk in humans. Results of this work will help in formulating policies for military surgeons who must treat personnel wounded by fragments of the alloys. Indications of unacceptable risks of exposure will also help determine the advisability of deploying (or developing) similar munitions. In year 4 of this project, metal-implanted mice in the two-year carcinogenicity study continue to be assessed for tumor development. At present, no tumors have been observed in the tungsten alloy implanted mice, but tumors have begun to form around the nickel pellet (positive control) after approximately 60 weeks post-implantation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2009
- Accession Number
- ADA503143
Entities
People
- John F. Kalinich
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine