Antingens for a Vaccine that Prevents Severe Malaria

Abstract

Malaria is the primary infectious disease threat facing the U.S. soldier, and is the leading cause of all causalities during tropical deployments. The long-term objective of this project is to identify and prepare the malaria parasite forms causing severe anemia, and then apply functional genomics and bioformatics tools to identify 15 to 30 proteins that could form the basis for an effective vaccine at both the pre-erythrocytic and blood stages of malaria infection. The project will then evaluate these lead candidates for their recognition by sera collected from immune individuals, in order to identify the leading 3 to 5 candidates for a blood stage vaccine that prevents severe malaria anemia.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2009
Accession Number
ADA503186

Entities

People

  • Patrick E. Duffy

Organizations

  • Center for Global Infectious Disease Research

Tags

DTIC Thesaurus Topics

  • Blood
  • Body Weight
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Health Services
  • Infection
  • Malaria
  • Medical Personnel
  • Proteins

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Parasitology and Pharmacology of Malaria.

Technology Areas

  • Biotechnology