Identification of Ovarian Cancer Susceptibility Genes Involved in Stromal-Epithelial Interactions

Abstract

The purpose of this project was to identify ovarian cancer susceptibility genes involved in stromal- epithelial cross talk. We have now genotyped 2138 samples for 1536 tagging, ns and miRNA binding site SNPs in 174 genes. Following Quality Control exclusions, the final dataset comprised 1839 samples (675 cases and 1164 controls) with genotype information for 1292 SNPs in 174 genes. We also genotyped 22 SNPs in 2985 cases and 2932 controls from six sites within the Ovarian Cancer Association Consortium, and the best 3 SNPs in PODXL (rs1013368), ITGA6 (rs13027811) and MMP3 (rs522616) in 7,139 cases and 7,851 controls from 12 sites in OCAC. None of these SNPs showed significant associations with ovarian cancer risk in pooled analysis, adjusted for study and age, under any model.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2009
Accession Number
ADA503499

Entities

People

  • Georgia Chenevix-Trench

Organizations

  • QIMR Berghofer Medical Research Institute

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Diseases And Disorders
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetic Variation
  • Genetics
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Ovarian Cancer
  • Proteins
  • Quality Control
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Manufacturing Engineering.
  • Molecular Biology and Genetics
  • Regression Analysis.