Process Research and Development of Antibodies as Countermeasures for C. botulinum

Abstract

This final report describes the design and construction of a CGMP facility for yeast and bacteria on the first floor and basement of Othmer Hall, the home for the University of Nebraska-Lincoln Biological Process Development Facility. Total cost for construction was $11,165,740, with the University of Nebraska-Lincoln providing $5,179,226 (46%) of the funding, USAMRMC providing $4,958,049 (45%), and JVAP providing $1,028,465 (9 %). This final report also describes the expression, purification and media optimization of a monoclonal antibody against serotype A botulinum neurotoxin.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2009
Accession Number
ADA503782

Entities

People

  • Michael Meagher

Organizations

  • University of Nebraska–Lincoln

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Fatty Acids
  • Health Services
  • Immunoglobulins
  • Liquid Chromatography
  • Organic Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Nuclear Civil Defense.
  • Technical Research and Report Writing.