CHD8, A Novel Beta-Catenin Associated Chromatin Remodeling Enzyme, Regulates Androgen Receptor Mediated Gene Transcription
Abstract
The activity of the androgen receptor (AR) is critical for normal prostate development and function, but AR activity also plays a major role in the development and progression of prostate cancer. To better understand the function of beta-catenin in AR mediated transcription, we have identified a novel chromatin remodeling enzyme, CHD8, that can associate with beta-catenin and functions in AR mediated gene transcription. Year 2 was focused on the continuing the first specific aim of this proposal (the interaction of CHD8 with beta-catenin and the androgen receptor) and starting the second specific aim (the function of CHD8 and beta-catenin at the PSA promoter). This work is required for the study of the function of CHD8 and beta-catenin in AR mediated transcription and the ultimate understanding of the role played by CHD8 in prostate cancer progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 2009
- Accession Number
- ADA504104
Entities
People
- Daniel A. Bochar
Organizations
- University of Michigan