Fish Oil Supplementation and Fatty Acid Synthase Expression in the Prostate: A Randomized Controlled Trial

Abstract

One in seven men over the age of 60 will be diagnosed with prostate cancer. Elucidation of early cellular changes that may predict progression to prostate cancer and the identification of factors that may inhibit or reverse these cellular changes would be of great clinical significance. Alteration of the fatty acid synthase (FAS) pathway is an early cellular change that has recently come under investigation. Overexpression of the lipogenic enzyme FAS has been noted in several tumor and pre-cancerous tissue types, including prostatic intraepithelial neoplasia (PIN) and prostate cancer and has been suggested as an independent predictor of disease stage. Additionally, inhibition of FAS has been demonstrated to induce apoptosis and reduce cell proliferation in cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2009
Accession Number
ADA504121

Entities

People

  • Jackilen Shannon

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Cells
  • Carcinoma
  • Cardiac Arrhythmias
  • Carrier Proteins
  • Cell Physiological Processes
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Fish Oils
  • Health Services
  • Lipids
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Tissues

Fields of Study

  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and genetic basis of cancer.
  • Oncology