Development of Targeted Nonionic Surfactant Vesicles for Treatment of Vascular Injury

Abstract

Inflammatory processes play a crucial role in cardiovascular injury and disease. Inflamed endothelial cells express adhesion molecules which are potential therapeutic delivery targets for reducing or disrupting inflammation. We have developed non-ionic surfactant vesicles (niosomes) that are specifically targeted to inflamed vascular cells. Niosomes are self assembly vesicles that can encapsulate therapeutic agents and can be delivered to an injured subject via an injection, through skin or in a gel or patch. In this paper, we will describe the synthesis of the niosomes, results of studies to determine binding to injured/inflamed endothelial cells, efforts to encapsulate anti-inflammatory agents, and initial animal data.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2008
Accession Number
ADA504588

Entities

People

  • Brenda Flam
  • Elizabeth Hood
  • Joel Strom
  • John Elliott
  • Karl Muffly
  • Michael Vanauker

Organizations

  • University of South Florida

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adhesion
  • Aneurysm
  • Anti-Inflammatory Agents
  • Blood
  • Cardiovascular Diseases
  • Cardiovascular System
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Endothelial Cells
  • Health Services
  • Inflammation
  • Molecules
  • Particles
  • Vascular Diseases
  • Vascular System Injuries

Fields of Study

  • Chemistry
  • Medicine

Readers

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  • Immunology and Pathology
  • Systems Analysis and Design