Nonhuman Primates are Protected from Smallpox Virus or Monkeypox Virus Challenges by the Antiviral Drug ST-246

Abstract

ST-246, a potent, orally available orthopox egress inhibitor, is safe and effective at preventing disease and death in small animal models (mice, rabbits, ground squirrels) challenged by different pathogenic poxv viruses including vaccinia virus, cowpox virus, ectromelia virus, and monkeypox virus. In this report, the antiviral efficacy of ST-246 was assessed in non-human primates infected with variola virus or monkeypox virus. The data indicate that once per day oral dosing with ST-246 protects animals from poxvirus disease as measured by reduction in viral load, appearance of lesions, and survival.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2009
Accession Number
ADA504600

Entities

People

  • Arthur J Goff
  • Carly Wlazlowski
  • Chelsea M. Byrd
  • Dennis Hruby
  • Eric M Mucker
  • Inger K. Damon
  • Jennifer Chapman
  • John Huggins
  • Josh Shamblin
  • Kevin Karem
  • Lisa Hensley
  • Nancy Twenhafel
  • Robert Jordan
  • Tom Larsen
  • Tove C. Bolken
  • Wendy Johnson

Organizations

  • Centers for Disease Control and Prevention

Tags

DTIC Thesaurus Topics

  • Animals
  • Anti-Infective Agents
  • Blood
  • Cell Count
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Infectious Diseases
  • Inhibitors
  • Lagomorphs
  • Lepidoptera
  • Poxviridae Infections
  • Rodents
  • Vaccines
  • Viral Load
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology

Readers

  • Virology (or Medical Virology).