Role of IRS1 and IRS2 in Modulating ErbB-induced Tumorigenesis

Abstract

Insulin receptor substrates 1 and 2 (IRSs) are adapter proteins which are required for the transforming ability of many oncogenes. Up to date, little is known about the interaction between IRSs and ErbB2 in epidermal growth factor receptor (ErbB2/Her2/Neu) amplified breast cancer. In a mouse study we found that overexpression of IRS2 had no effect upon ErbB2 induced mammary tumorigenesis in vivo. Whole mounts and hematoxylin and eosin (H&E) analysis revealed no major morphological differences in ductal branching and tumor type(solid adenocarcinomas) between ErbB2 and bigenic (ErbB2/IRS2) overexpressing mice. Furthermore, the metastatic potential of ErbB2 is not changed by additional overexpression of IRS2.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 2009
Accession Number
ADA504652

Entities

People

  • Beate Litzenburger

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Biology
  • Biomedical Research
  • Blood
  • Blood Vessels
  • Breast Cancer
  • Cancer
  • Cell Line
  • Diseases And Disorders
  • Epithelial Cells
  • Gene Therapy
  • Growth Factors
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Peptide Growth Factors
  • Proteins
  • Skin Diseases

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics