Vitamin D, Vitamin D Receptor Polymorphisms, and Breast Cancer Aggressiveness in African American and European American Women
Abstract
In 509 consecutive breast cancer patients, we found the majority of the breast cancer patients were vitamin D insufficient or deficient at the time of diagnosis. In premenopausal women, serum 25-hydroxyvitamin D levels were lower in those with invasive cancer, particularly those with cancer of high aggressive characteristics including high tumor grade, estrogen receptor negative, and triple negative subtype, compared to patients with carcinoma in situ. The estimated odds ratios and 95% confidence intervals associated with high versus low vitamin D levels in premenopausal women were 0.39 (0.17-0.91) of invasive cancer, 0.32 (0.13-0.78) of poorly differentiated cancer, 0.24 (0.08-0.71) of estrogen receptor negative cancer, and 0.14 (0.03-0.60) of triple negative cancer. No similar associations were observed in postmenopausal women. Our data showed that low vitamin D levels were related to high risk of invasive breast cancer, particularly cancer of high aggressive characteristics in premenopausal but not postmenopausal women, indicating that vitamin D may prevent breast cancer progression and reduce high aggressive cancer risk in young women.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2009
- Accession Number
- ADA504754
Entities
People
- Song Yao
Organizations
- Health Research, Incorporated