ER/PR Status of the Originating Cell of ER-Negative Breast Cancer

Abstract

The goal of this study is to test whether ER - breast cancers arise from ER? or ER+ mammary cells. We specifically hypothesize that ER is absent in the originating cell of ER-negative breast cancer. Although until now it has been technically difficult to test it, we have developed a unique mouse model based on the RCAS-TVA technology that allows us to trace the ER status of the cancer-originating cell. It is now possible to test this hypothesis in experimental mice. In this funding period, we have generated mouse lines and viruses for the experiments proposed, and have found that the cell origin of breast cancer affects the ER status of breast cancer. In addition, we have found that somatic activation of growth factor signaling induces estrogen-independent tumor initiation.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2009
Accession Number
ADA505073

Entities

People

  • Yi Li

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Biomolecules
  • Breast Cancer
  • Cancer
  • Cell Lineage
  • Cell Physiological Processes
  • Cells
  • Chemical Compounds
  • Department Of Defense
  • Estrogens
  • Glands
  • Growth Factors
  • Infection
  • Mammary Glands
  • Neoplasms
  • Wound Infections

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.