Aerobic Exercise, Estrogens, and Breast Cancer Risk
Abstract
With approximately 180,000 new cases reported in 2008, breast cancer continues to be the most frequently diagnosed cancer in American women and the second leading cause of death in this population.1 In recent systematic literature reviews, physical activity has been shown to be significantly associated with decreases in breast cancer risk. The goal of this training grant is to investigate changes in the hormonal profile of exercising women as one of the proposed mechanisms by which physical activity might lead to reductions in breast cancer risk. Specifically, this research project is a randomized clinical trial investigating the effects of a 16-week, aerobic exercise intervention on endogenous sex hormone levels and estrogen metabolism of sedentary, healthy, eumenorrheic, premenopausal women. Up-to-date highlights of this study include: 1) completion of recruitment and randomization efforts, 2) study completion by 290 women accounting for 90.6% of the total sample size, and 3) assay of more than half of total blood and urine samples. Participants in the last recruitment wave are expected to finish the study by the end of September 2009. Analyses of biological samples are scheduled to take place at the beginning of June 2009 and at the end of the study.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2009
- Accession Number
- ADA505262
Entities
People
- Alma J. Smith
Organizations
- University of Minnesota