Role of Hsp90 in Androgen-Refractory Prostate Cancer

Abstract

A major challenge in prostate cancer research is to develop novel therapies that can delay or prevent the progression of androgen-sensitive prostate cancer to androgen-independence. Androgen receptor (AR) is often overexpressed and plays an essential role in androgenrefractory prostate tumors. Our preliminary studies suggest that heat shock protein 90 (Hsp90) is required for androgen-independent AR nuclear localization in androgen-refractory prostate cancer cells. This project will test our research hypothesis that Hsp90 plays a critical role in ligand-independent AR nuclear localization, an essential step leading to androgen-refractory prostate cancer. In the last year of the funding period, we showed that Hsp90 deacetylation by HDAC6 is a critical step involved in castration resistance of prostate cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2009
Accession Number
ADA505267

Entities

People

  • Zhou Wang

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Castration
  • Cell Line
  • Cells
  • Diseases And Disorders
  • Genetic Code
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Resistance
  • Tissues
  • Transcription Factors
  • United States
  • Virotherapy

Readers

  • Marine Propulsion Engineering and Naval Architecture
  • Prostate Cancer Biology.