Regulation and Action of SKP2 in Cell and Tumor Models: Mechanisms Underlying Aggressive Growth in Basel-Like Breast Cancer

Abstract

The objective of this research is to further our understanding of the molecular mechanisms underlying the aggressive growth of estrogen receptor (ER)-negative, basal-like breast tumors. My goal is to determine if SKP2 is a viable new therapeutic target to specifically treat patients who have tumors that are independent of ER signaling. The most significant finding during this research period is that SKP2 protein was expressed in 60% (21 of 35) of ER-negative tumors, 25% (26 of 104) of ER-positive tumors, and 10% (5 of 50) reductive mammoplasty tissues. These data suggest that SKP2 overexpression is a phenomenon associated with ER-negative tumors. With an additional 150-300 ER-negative tumor cases this relationship will be better elucidated.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2009
Accession Number
ADA505309

Entities

People

  • Katerina Fagan-solis

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biology
  • Biomedical Research
  • Biotechnology
  • Breast Cancer
  • Cell Cycle Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Compounds
  • Department Of Defense
  • Diseases And Disorders
  • Estrogens
  • Gene Expression
  • Medical Personnel
  • Neoplasms
  • Proteins

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics