Early Stage Treatment of Compartment Syndrome Using Polymer Sol-Gel Composite Growth Factor Delivery Wound Dressings

Abstract

Compartment syndrome (CS) as a result of blast or traumatic injury is a devastating problem in the battlefield. The ultimate goal of this study is to develop an integrated toolkit of novel, biodegradable wound dressing composites for early stage treatment of CS. Composites made from the tyrosine-based block copolymers and silica based sol-gels were designed as an absorbent to remove fluid from injured muscle compartments and as wound dressings to deliver therapeutic agents to the compartment. This in vitro study reports the controlled release of protein analog and antibiotics from the room temperature processed sol-gel particles. Furthermore, this study reports the fabrication of the composite wound dressings with mechanical properties for the clinical application.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2008
Accession Number
ADA505821

Entities

People

  • B. Kim
  • C. Knabe
  • D. Devore
  • H. Qu
  • M. Costache
  • P. Ducheyne
  • S. Radin

Organizations

  • University of Pennsylvania

Tags

Communities of Interest

  • Counter IED
  • Weapons Technologies

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Block Copolymers
  • Chemical Synthesis
  • Chemistry
  • Composite Materials
  • Copolymers
  • Fabrication
  • Glass Transition Temperature
  • Materials
  • Materials Processing
  • Materials Science
  • Mechanical Properties
  • Modulus Of Elasticity
  • Molecules
  • Particles
  • Polymeric Films
  • Polymers

Readers

  • Materials Science and Engineering.
  • Nanocomposite Materials Science
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Microelectronics