Doxycycline Inhibits Vascular Leakage and Prevents the Development of Pulmonary Edema
Abstract
The Vascular Leak Syndrome induced by blast injuries, burns, asphyxiation, and other injuries lead to progressive pulmonary edema, as well as tissue and limb swelling that contribute to morbidity and mortality of soldiers on the battlefield. The main goal of our research is the development and validation of novel therapies to prevent and reverse vascular leak syndromes. Our findings indicate that doxycycline, a commonly used antibiotic, inhibits vascular leak in a spectrum of pathologies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2008
- Accession Number
- ADA505844
Entities
People
- Elke Pravda
- Irit Adini
- Judah Folkman
- Lauren Bazinet
- Ofer Fainaru
- Ofra Benny
- Robert D'amato