Disruption of the Circadian Rhythms of Gene Expression and the Development of Breast Cancer

Abstract

This project investigated the effects of rhythm disruption in mice on the expression of a wide range of genes in mammary tissue, the growth of MCF-7 xenografts and the growth, metastasis and gene expression in spontaneous mouse mammary tumors. Subjecting mice to a simulated shiftwork schedule altered the pattern and level of expression of clock gene transcription factors and genes that are involved in the cell cycle. We have also found that the formation of secondary lung tumors is enhanced by a simulated shiftwork protocol.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2009
Accession Number
ADA506316

Entities

People

  • David J. Kennaway

Organizations

  • University of South Australia

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Division
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Circadian Rhythms
  • Gene Expression
  • Mammary Glands
  • Metastasis
  • Neoplasms
  • Simulations
  • Transcription Factors
  • Tumor Cell Line
  • Xenografts

Fields of Study

  • Biology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Molecular Biology and Genetics