System Design, Algorithm Development, and Verification for Optoacoustic Molecular Imaging of Protease Expression in Breast Cancer

Abstract

Optoacoustic tomography (OAT) is an emerging, hybrid technique that is non-invasive and uses non-ionizing radiation. No one has yet developed a molecular probe for early detection of proteases in breast cancer using OAT. Our group is developing a molecular probe and an optoacoustic imaging system to address this. During the first year of this project, we have implemented the code that simulates the ideal optoacoustic system. We have compared existing 2D algorithms in OAT with respect to contrast, resolution, noise and signal detectability. We also explored the effect of variable speed of sound and ultrasonic attenuation on image quality. We derived new techniques to address these physical effects that could cause image distortion and blurring.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2009
Accession Number
ADA506325

Entities

People

  • Dimple Modgil

Organizations

  • University of Chicago

Tags

Communities of Interest

  • Air Platforms
  • Biomedical
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Acoustic Propagation
  • Acoustic Waves
  • Acoustics
  • Algorithms
  • Biological Sciences
  • Breast Cancer
  • Detection
  • Detectors
  • Distortion
  • Geometry
  • Imaging Techniques
  • Neoplasms
  • Photoacoustic Tomography
  • Radiation
  • Sound Waves
  • Three Dimensional
  • Tomography

Fields of Study

  • Physics

Readers

  • Acoustical Oceanography.
  • Image Processing and Computer Vision.
  • Spectroscopy.