Site-Specific Differentiation of Fibroblasts in Normal and Scleroderma Skin

Abstract

The results from year 2 of funding applied novel biomarkers to address whether systemic sclerosis, a fibrosing disorder, involves changes in cell positional identity. Long noncoding RNAs are the predominant position specific output of the HOX loci, and their misexpression in systemic sclerosis suggests that altered fibroblast positional identity is involved.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2009
Accession Number
ADA506474

Entities

People

  • Howard Y. Chang

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Cells
  • Computational Biology
  • Coordinate Systems
  • Dermatology
  • Diseases And Disorders
  • Endothelial Cells
  • Epidermis
  • Epithelial Cells
  • Fibroblasts
  • Gene Expression
  • Genetics
  • Neoplasms
  • Proteins
  • Skin Cancer
  • Skin Diseases
  • Systems Biology
  • Transcription Factors

Readers

  • Immunology and Pathology
  • Molecular Biology and Genetics
  • Molecular Genetics