Angiogenic Signaling in Living Breast Tumor Models
Abstract
In this grant we propose to elucidate the signaling pathway that translates VEGFR activation into elevated vessel permeability, in endothelial cells within living breast tumor models. The working hypothesis is that the signaling pathway involved is a constitutively active form of the pathway shown for healthy mesenteric microvessels. Progress to date includes the training of personnel in the laboratory, the completion of instrumentation development for a novel method for the measurement of convective flow in tumors in vivo and extensive analysis of its capabilities, extensive investigation of breast tumor exctracellular matrix using second harmonic generation, extensive analysis of the abilities of a novel permeability measurement technique and numerous preliminary experiments to establish methodology for tasks to commence in upcoming years.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2009
- Accession Number
- ADA506632
Entities
People
- Edward B Brown
Organizations
- University of Rochester Medical Center