Residential Segregation, Housing Status, and Prostate Cancer in African American and White Men
Abstract
Racial-residential segregation which reduces the quality of housing has been proposed as a fundamental social cause of race disparities in health. This study, which included 378 African American and 496 white prostate cancer cases and controls, assessed housing status in relation to prostate cancer risk and aggressiveness and in relation to DNA damage in tumor and adjacent normal tissue. Housing built before 1950, a measure known to be associated with lead exposure in children, was the housing status measure most often associated with prostate cancer outcomes, in particular higher Gleason grade and stage of disease. When PAH adduct levels, a measure of DNA damage, was assessed, lower census tract home ownership was associated with lower PAH adduct levels in tumor adjacent normal tissue of African American men. Our findings suggest that housing may be a risk factor for prostate cancer aggressiveness and prostate cancer disparities and that lead exposure and PAH adducts may be two routes through which housing influences prostate cancer outcomes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2009
- Accession Number
- ADA507144
Entities
People
- Christine Neslund-dudas
Organizations
- Henry Ford Health