Modulators of Response to Tumor Necrosis-Related Apoptosis-Inducing Ligand (TRAIL) Therapy in Ovarian Cancer

Abstract

Ovarian Cancer is the leading cause of death from gynecologic cancers in the developed world. We have previously identified a homeobox gene, Six1, which is overexpressed in ovarian cancers as compared to normal ovarian surface epithelium. Overexpression of Six1 is associated with resistance to Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) based therapies. We have discovered that this resistance in ovarian cancers is likely related to over-expression of the TRAIL decoy receptor DcR2. On-going studies are evaluating the mechanism and significance of this finding on the way to designing new treatments for ovarian cancer.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2009
Accession Number
ADA508266

Entities

People

  • Kian Behbakht

Organizations

  • University of Colorado Health

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Cancer
  • Carcinoma
  • Cell Line
  • Cells
  • Chemotherapy
  • Diseases And Disorders
  • Gynecologic Cancers
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Ovarian Cancer
  • Polymerase Chain Reaction
  • Resistance
  • Two Dimensional

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