A Blast Model of Traumatic Brain Injury in Swine

Abstract

Although blast-induced traumatic brain injury (BI-TBI) is a significant cause of morbidity and behavioral dysfunction in warfighters returning from Iraq, laboratory models are not currently available to study the mechanisms underlying this critical injury and develop new therapies to treat survivors. Many TBI models are performed in rodents, and data from these models have been used as a basis for several disappointing Phase III clinical trials in humans with TBI. The failure of these trials may, in part, be due to differences between the rodent and human (or pig) brain. The development of a large-animal model of BI-TBI will revolutionize the study of this pressing clinical problem and rapidly facilitate the development of novel therapies to treat injured military personnel. Therefore, the purpose of the experiments proposed is to develop a survival model of BI-TBI in swine.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2009
Accession Number
ADA508616

Entities

People

  • Samuel S. Panter

Organizations

  • Northern California Institute for Research and Education

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Air Guns
  • Biomedical Research
  • Blast Tubes
  • Body Armor
  • Brain Injuries
  • Calibration
  • Clinical Trials
  • Diameters
  • Dysfunction
  • Explosive Devices
  • Explosives
  • Guns
  • Head Injuries
  • Improvised Explosive Devices
  • Medical Personnel
  • Military Personnel

Fields of Study

  • Medicine

Readers

  • Computational Modeling and Simulation
  • Neurotrauma and Rehabilitation Medicine.
  • Oncology