A Role for TACI in Prostate Neoplasia

Abstract

This research study proposed that TNF- family growth factors, BAFF and APRIL play a role in prostate cancer. Our hypothesis proposed that APRIL provides a proliferative signal to normal prostate epithelial cells by means of an unknown receptor. We postulated that TACI is an antagonist receptor which functions to regulate APRIL-mediated proliferation of cells by inducing apoptosis and thereby maintaining the normal glandular structure. The loss of TACI expression in prostate cells therefore conceivably results in an imbalance in homeostasis resulting in the aberrant accumulation of cells which become susceptible to transformation. Our hypothesis anticipated that the addition of APRIL would enhance cell growth whereas the addition of TACI-Ig would either reduce cell growth or induce apoptosis. This did not happen and we did not see any significant changes in the relative numbers of hyperdiploid cells as determined by propidium iodide flow cytometry. Because of the negative results, the study was terminated early and the grant relinquished. Dr. VonBulow no longer works for Indiana University.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2008
Accession Number
ADA508618

Entities

People

  • Gotz-ullrich Vonbulow

Organizations

  • Indiana University

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Apoptosis
  • Biological Sciences
  • Biomedical Research
  • Cell Line
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Epithelial Cells
  • Growth Factors
  • Information Operations
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Tissues
  • Universities

Readers

  • Clinical Trial Research.
  • Molecular Biology and Genetics
  • Oncology (Cancer Research).