Determination of the Role of Estrogen Receptors and Estrogen Regulated Genes in B Cell Autoreactivity

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that occurs preferentially in women. In murine models of SLE, it is clear that increased or sustained high physiologic levels of estradiol can accelerate onset of disease and exacerbate disease severity. We have shown that estradiol alters B cell maturation in vivo but does so in a genetically restricted fashion. We have also shown that estradiol can act directly on B cells to alter B cell receptor (BCR) signalling strength. This proposal is to understand which estrogen receptors mediate the effects of estradiol on B cell survival, maturation and activation in order to assess whether hormonal manipulation has a potential therapeutic role in SLE. The proposal is further designed to ask why estradiol affects B cell function in mice of one genetic background but not another.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2009
Accession Number
ADA509183

Entities

People

  • Betty Diamond

Organizations

  • The Feinstein Institute for Medical Research

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Apoptosis
  • Autoimmune Diseases
  • Biomedical Research
  • Bone Marrow
  • Bones
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Estrogens
  • Hormones
  • Immune System
  • Lupus
  • Lymphatic System
  • Maturation
  • Sex Hormones

Fields of Study

  • Biology
  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Immunology and Pathology
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech