Transrectal Near-Infrared Optical Tomography for Prostate Imaging
Abstract
The objective of this research is to explore the technology of trans-rectal near-infrared (NIR) optical tomography for accurate, selective prostate biopsy. Prostate cancer is the most common non-dermatologic cancer in American men. Prostate cancer suspicion is typically based on an elevated serum prostate-specific antigen (PSA) level or a suspicious nodule found during a digital rectal exam (DRE). When the PSA level is elevated or the DRE shows abnormal, there is a 25 % chance that cancer is present. The existence of prostate cancer can only be confirmed by a needle biopsy that is guided by trans-rectal ultrasound (TRUS). Since there are no pathognomonic findings for prostate cancer on ultrasound imaging, biopsies are taken following a systematic pattern throughout the prostate with preference given to the peripheral zone wherein most cancer are found. The accuracy of biopsy is questionable and many men undergo multiple biopsies due to the lack of a more specific/sensitive imaging modality. Pathologic studies have demonstrated positive correlation between increased micro-vessel density and the onset of the disease. Near-infrared (NIR) optical tomography is known of sensitive to blood based contrast, therefore trans-rectally implemented NIR optical tomography may provide a new way of assessing the prostate cancer. One of the outcomes of trans-rectal NIR tomography of the prostate would be a more accurate imaging guidance for targeted prostate biopsy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2009
- Accession Number
- ADA509892
Entities
People
- Daqing Piao
Organizations
- Oklahoma State University–Stillwater