Natural History of Plexiform Neurofibromas in NF1. Addendum

Abstract

The overall goal of this study was to use volumetric MRI to define the natural history of untreated plexiform neurofibromas in patients with NF1. MRIs were obtained from patients with untreated plexiform neurofibromas and sent to a central location for volumetric analysis. Following the initial analysis using a manual method to delineate tumor boundaries, data were reanalyzed using two separate approaches to semi-automated analysis. Overall, most tumors, regardless of body site, remained stable in size during the course of study. There was a trend towards more rapid growth in younger patients, however. In addition, the imaging characteristics of superficial and abdominal plexiform neurofibromas have been described. The results have demonstrated that volumetric MRI provides a reproducible and practical approach to measurement of the growth of plexiform neurofibromas. This approach is now the standard approach in use to measure response of plexiform neurofibromas to therapy, including in the clinical trials being conducted by the NF Consortium.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2008
Accession Number
ADA510000

Entities

People

  • Bruce R. Korf

Organizations

  • University of Alabama

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abdomen
  • Data Analysis
  • Diseases And Disorders
  • Electronic Mail
  • Health Services
  • Information Science
  • Medical Personnel
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Sciatic Nerve
  • Spine
  • Statistical Analysis
  • Therapy
  • Three Dimensional
  • Two Dimensional
  • United States

Fields of Study

  • Medicine

Readers

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