The Effect of Hypotensive Resuscitation and Fluid Type on Mortality, Bleeding, Coagulation and Dysfunctional Inflammation in a Swine Grade V Liver Injury Model
Abstract
Objectives: To determine the efficacy and safety of lyophilized plasma for the treatment of multisystem trauma in pigs. Methods: 1. 32 swine at 2 institutions underwent femur fracture, controlled hemorrhage (30% estimated blood volume), hypothermia (33 deg C) and resuscitation with normal saline and Grade V liver injury followed by 30 minutes of hemorrhagic shock without resuscitation. Animals were then randomized to Fresh Frozen Plasma (FFP), Lyophilized Plasma (LP), 1:1 PRBC:FFP, and 1:1 PRBC:LP. Animals were followed for four hours post liver injury. Physiologic parameters, coagulation assays and inflammatory mediators were compared. Results: 1. There were no significant differences in any physiologic parameters (Mean Arterial Pressure, Heart Rate, Mortality, or Blood Loss) between the groups. Coagulation parameters did not differ between groups. Analysis of inflammatory markers showed significantly lower values for LP animals compared to FFP animals at 2 hours post injury. Conclusion: LP is as safe and effective as FFP for resuscitation in a severe hemorrhagic shock model and it may reduce harmful inflammation associated with severe trauma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2009
- Accession Number
- ADA510127
Entities
People
- Martin A. Schreiber
Organizations
- Oregon Health & Science University