Bioengineering Multifunctional Quantum Dot-Polypeptide Assemblies and Immunoconjugates for the Ablation of Advanced Prostate Cancer Disease
Abstract
A significant amount of progress has been made with respect to the work described in the above proposal. We have evaluated cationic amphipathic peptide based fusion peptides (Specific Aim 1) and immunoconjugates (Specific Aim 2) for the targeted ablation of prostate cancer cells. These results have resulted in a manuscript published recently in the journal Cancer Research (see Appendix 1). Secondly, we have investigated the role of the Prostate-Specific Membrane Antigen (PSMA) in the differential intracellular sorting of fluorescent quantum dots by prostate cancer cells (Specific Aim 3). A manuscript relating to these results in currently in preparation. Future work will involve the use of protein engineering techniques in order to generate higher efficacy peptides targeting prostate cancer cells followed by their self assembly on quantum dots in order to general multifunctional assemblies for the targeted ablation and imaging of prostate cancer disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2009
- Accession Number
- ADA511040
Entities
People
- Srivatsan Kidambi
Organizations
- Massachusetts General Hospital