The Loss of Pin1 Deregulates Cell Cycle Progression and Promotes the Development of Breast Cancer

Abstract

Pin1 regulates many factors that are relevant to breast cancer, such as c-Jun, c-Myc, cyclin D1, and cyclin E. However the function of Pin1 in a normal cell is still poorly understood. Thus the role of Pin1 in G0/G1 to S-phase progression and genomic instability was examined in this research project.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2009
Accession Number
ADA511532

Entities

People

  • Brian Lew

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood Coagulation Factor Inhibitors
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Fibroblasts
  • Genomic Instability
  • Growth Factors
  • Instability
  • Neoplasms
  • Phase
  • Phase Transformations
  • Proteins
  • Scintillation Counters
  • Transitions

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics