An Interventional MRI Technique for the Molecular Characterization of Heterogeneous Intra-Prostatic Dynamic Contrast Enhancement

Abstract

The biological characterization of an individual patient's tumor by non-invasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of MRI contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely co-localizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patient with prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2004
Accession Number
ADA511673

Entities

People

  • Ahmed Gharib
  • Axel Krieger
  • C. N. Coleman
  • Cynthia Ménard
  • David Thomasson
  • Emanuel Petricoin
  • Ergin Atalar
  • Gabor Fitchtinger
  • Jonathan Coleman
  • Karen Ullman
  • Kevin Camphausen
  • Lance A. Liotta
  • Louis L. Whitcomb
  • Peter Guion
  • Peter L Choyke
  • Robert C. Susil
  • Robert Grubb
  • Sandeep K. Gupta
  • Virginia Espina

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Arteries
  • Biology
  • Biomedical Engineering
  • Blood
  • Contrast
  • Gene Therapy
  • Health Services
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Molecular Biology
  • Neoplasms
  • Oncology
  • Prostate
  • Prostate Cancer
  • Radiation Oncology
  • Small Molecules
  • Therapy

Fields of Study

  • Medicine
  • Physics

Readers

  • Molecular and genetic basis of cancer.
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech