New Strategy for Prostate Cancer Prevention Based on Selenium Suppression of Androgen Receptor Signaling

Abstract

We tested the efficacy of methylselenocysteine (MSC) and finasteride in preventing the clonal expansion of early stage, small volume prostate cancer using a tumor xenograft model. When used alone, MSC had little effect on tumor growth, whereas finasteride was only effective for a short duration. However, the combination was more effective than the single treatments. Due to the small sample size, the observed effects were not statistically significant. A repeat of the experiment with larger sample size is needed to corroborate the findings. We also demonstrated a synergy between emodin and finasteride in suppressing androgen signaling in prostate cancer cells. The combination was more effective in inhibiting cell proliferation and inducing cell death. This provides another option for combined androgen blockade in prostate cancer chemoprevention.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2009
Accession Number
ADA511818

Entities

People

  • Haitao Zhang

Organizations

  • Tulane University of Louisiana

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Apoptosis
  • Cell Physiological Processes
  • Cells
  • Drug Therapy
  • Gene Expression
  • Molecules
  • Neoplasms
  • Polymerase Chain Reaction
  • Prostate
  • Prostate Cancer
  • Proteins
  • Selenium
  • Skin Cancer
  • Vitamin E
  • Xenografts

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).
  • Prostate Cancer Biology.
  • Regression Analysis.

Technology Areas

  • Biotechnology