Biomarkers of Risk for Post-traumatic Stress Disorder (PTSD)

Abstract

The objective of this proposal is to study genetic and neuroendocrine biomarkers of risk in a carefully assessed population of military personnel who have recently returned from war zones. The target sample includes 300 men and women who have recently returned from hazardous deployment and are undergoing a comprehensive assessment of symptoms and stressors in a related 12-month longitudinal study. To date, we have enrolled 203 subjects. Samples of saliva have been obtained from all 203 enrolled subjects for analysis of DNA and candidate genes. Cortisol samples have been obtained from 157 of these subjects. Hormone and genetic data will be used to predict the development of PTSD and chronic PTSD. In addition, interactions of these biomarkers with trauma severity and other stressors as well as social supports will be examined.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2009
Accession Number
ADA511924

Entities

People

  • Audrey R. Tyrka

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anticonvulsants
  • Anxiety Disorders
  • Biological Factors
  • Biological Markers
  • Depression
  • Digestive System Processes
  • Diseases And Disorders
  • Electric Stimulation Therapy
  • Genetics
  • Health Services
  • Medical Personnel
  • Mood Disorders
  • Pituitary And Hypothalamic Hormones And Analogues
  • Psychiatry
  • Psychology
  • Students
  • Traumatic Stress Disorder

Fields of Study

  • Psychology

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology