Epigenetic Control of Prolyl and Asparaginyl Hydroxylases in Prostate Cancer
Abstract
In many solid tumors, including prostate cancer, hypoxia-inducible factors (HIF) are up-regulated compared to their normal tissue counterparts. These HIF molecules are transcription factors, and supply the cancer with the proper proteins necessary for metabolism as well as angiogenesis. Recently, a set of proteins known as prolyl and asparaginyl hydroxylases (PHD and AHD respectively) have been shown to be essential in the regulation of HIF, and in some cancers have been transcriptionally and translationally silenced. We therefore proposed a study that focuses on the epigenetic control of these crucial enzymes. In addition, recent evidence has demonstrated a potential role for androgen insensitivity on the effect of suppression of these enzymes. In this report, we present data demonstrating our first findings of PHD expression in prostate cancer cell lines. Furthermore, we begin to identify specific epigenetic mechanisms that may play a major role in the transcriptional and translational control of these enzymes. Last, we will explain our future direction of the project for the remainder of the award period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2009
- Accession Number
- ADA511993
Entities
People
- Adam J. Case
Organizations
- University of Iowa