Beta 2-Microglobulin: A Novel Therapeutic Target for the Treatment of Human Prostate Cancer Bone Metastasis

Abstract

This proposal focuses on defining the role of beta 2-microglobulin (beta2-M) as a growth factor and signaling molecule contributing to prostate cancer bone metastasis. In this proposal, we proposed two Aims. Specific Aim 1 is to investigate the possible signaling pathway regulated by beta2-M in human prostate cancer cells with specific emphasis on the role of bradykinin (BK) receptor as the possible mediator of beta2-M signaling. We will define signaling transduction pathway mediated by beta2-M in promoting osteomimicry and prostate cancer cell growth and bone metastasis. Specific Aim 2 is to determine the effectiveness of BKM-1740, a BK receptor antagonist chemically conjugated with bisphosphonate known to accumulate in bone, in the inhibition of prostate cancer growth in mouse bone. By targeting BK receptor on the cell surface of prostate cancer cells using a synthetic BK inhibitor, BKM-1740, we expect this will increase prostate cancer cell death in bone.

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Document Details

Document Type
Technical Report
Publication Date
Mar 14, 2009
Accession Number
ADA511994

Entities

People

  • Leland W. Chung

Organizations

  • Emory University

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Biological Factors
  • Bone Diseases
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chemotherapy
  • Culture Techniques
  • Epithelial Cells
  • Gene Expression
  • Growth Factors
  • Peptides
  • Prostate Cancer
  • Proteins
  • Three Dimensional
  • Two Dimensional

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Aerospace Research.
  • Immunology and Pathology
  • Oncology