Molecular Genetic Studies of Bone Mechanical Strain and of Pedigrees with Very High Bone Density

Abstract

The primary goal of the proposed work is to identify the genes and their functions involved in mediating the anabolic response to mechanical stress. During the past year, we have used state-of-the-art technologies to investigate the role of a number of potential candidate genes in mediating skeletal anabolic response to mechanical loading. We found that modulation of leptin signaling influences mechanical loading response in the skeleton. We have also established using mice with conditional disruption of IGF-I in osteoblasts that local IGF-I expression in bone is essential for skeletal anabolic effects of exercise. On the other hand, disruption of formin- 2, a mechanoresponsive gene, did not influence skeletal anabolic response to mechanical loading. We believe that successful accomplishment of the proposed studies will provide a better understanding of the molecular mechanisms involved in identifying the genes and their function as related to mechanical stress.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2009
Accession Number
ADA512753

Entities

People

  • Subburaman Mohan

Tags

DTIC Thesaurus Topics

  • Bone And Bones
  • Bone Diseases
  • Bone Fractures
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Data Analysis
  • Department Of Veterans Affairs
  • Gene Expression
  • Genetics
  • Growth Factors
  • Health Services
  • Mechanical Properties
  • Osteoblasts
  • Osteogenesis
  • Osteoporosis
  • Peptide Growth Factors

Readers

  • Immunology and Pathology
  • Mechanical Engineering/Mechanics of Materials.
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology