Mechanism of Selenium Chemoprevention and Therapy in Prostate Cancer

Abstract

Prevention trials demonstrated that selenium is a promising chemopreventive agent for prostate cancer. Selenium inhibited human prostate cancer cell growth, blocked cell cycle progression, and induced apoptotic cell death. We have demonstrated a novel mechanism of selenium anticancer action in which selenium markedly reduces androgen receptor (AR) expression and AR-mediated gene expression including prostate-specific antigen (PSA) in human prostate cancer cells in vitro and in vivo. Based on our novel finding that selenium disrupts AR signaling by reducing AR expression, it is conceivable that selenium (reducing AR expression) might improve the efficacy of androgen deprivation therapy. In this application, we will test the effects of selenium on prostate cancer therapy.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2009
Accession Number
ADA513332

Entities

People

  • Allen C Gao

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Cell Physiological Processes
  • Degradation
  • Deprivation
  • Drug Therapy
  • Gene Expression
  • Inhibition
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Rna Stability
  • Selenium
  • Selenium Compounds
  • Therapy

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology