Serum Ropivacaine Concentrations and Systemic Local Anesthetic Toxicity in Trauma Patients Receiving Long-Term Continuous Peripheral Nerve Block Catheters
Abstract
Ropivacaine is a long-acting local anesthetic used frequently for peripheral nerve blocks and continuous peripheral nerve block catheters. Combat trauma patients at Walter Reed Army Medical Center often receive continuous peripheral nerve block catheters as part of their pain regimen. These catheters remain in situ for several days to weeks. In this study, we evaluated the free ropivacaine drug levels over time in trauma patients by measuring the serum concentration of bound and unbound local anesthetic. The corresponding 1-acid glycoprotein concentration in patients with prolonged ropivacaine infusions was also measured.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2010
- Accession Number
- ADA513574
Entities
People
- Anthony Dragovich
- Chester C. Buckenmaier
- Geselle Mcknight
- Kyung H. Kwon
- Lisa L. Bleckner
- Saiid Bina
Organizations
- Walter Reed Army Institute of Research