Detection of Prostate Cancer Progression by Serum DNA Integrity
Abstract
Toward the objective/hypothesis of obtaining additional diagnostic and prognostic insight through the analysis of tumor-related DNA integrity and methylation in patient serum, we continue to procure prostate patient specimens and develop optimized assessment assays. We have utilized prostate cell lines and tumor specimens for the assay optimization and validation. In a study of 57 prostate patients, we found significant differences of LINE1 status in patients compared to normal healthy male. The data is being assembled in a manuscript for submission to a peer reviewed journal. In the coming year, more PCA patients will be accrued as well as further accrual of serum at defined treatment intervals. Assays for the markers will be carried out for LINE1 and other promising biomarkers for clinical utility validation. We will also continue our efforts in discovering additional clinically relevant DNA biomarkers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2009
- Accession Number
- ADA514206
Entities
People
- Dave S. Hoon