Effect of a High Bone Turnover State Induced by Estrogen Deficiency on the Development and Progression of Breast Cancer Bone Metastases
Abstract
Aromatase inhibitors (AIs), effective treatment for breast cancer, block estrogen synthesis. Increased bone resorption and decreased bone mineral density (BMD) are predicted consequences. Four-week-old and 16-week-old female Balbc/ICR Swiss athymic mice were treated with the AI letrozole (5 mg/kg/day) or control. Four-week-old female athymic mice treated with letrozole for 16 weeks had increased BMD compared to control at the total body (p<0.0001), mid femur (P<0.0001) and tibia (0.0002), but there was no difference in BMD at the spine or distal femur. Sixteen-week-old female athymic mice treated with letrozole for 26 weeks had higher BMD compared to control at the total body (p<0.0001), but there was no difference in BMD between the treatment groups at the spine, distal femur or tibia. Immunocompetent 4-week-old female C57B6 mice treated with letrozole for 26 weeks had decreased BMD at the total body (p<0.0001), spine (p=0.0143), femur (p<0.0001) and tibia (p=0.0002) compared to control. The AI letrozole has variable effects on BMD in young versus old athymic mice. Furthermore, there are differing effects of AI therapy on BMD in athymic versus immunocompetent mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2008
- Accession Number
- ADA514558
Entities
People
- Wende M. Kozlow
Organizations
- University of Virginia