A Novel Method for the Capture of Potential Biomarkers from Breast Cancer Tissue and Serum
Abstract
This concept award was funded to develop the use of a bacterial toxin (alpha toxin) from C. Septicum to capture glycosylphosphatidyltnositol anchored proteins (GPI-APs) from breast cancer tissue and serum for identification by mass spectrometry. The rationale that supports this research is that there are increases in the levels of enzymes that produce the GPI anchor likely leading to increased levels of GPI-APs on the tumor cell. The continued selection of this molecular alteration must be providing a growth advantage to tumor cells. Therefore, identification of the proteins that are GPI-anchored in breast cancer and not normal breast tissue may lead to new diagnostic and therapeutic targets for breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2009
- Accession Number
- ADA514649
Entities
People
- Karen Abbott
Organizations
- University of Georgia Research Foundation