Inference of Antibiotic Resistance and Virulence Among Diverse Group A Streptococcus Strains Using emm Sequencing and Multilocus Genotyping Methods
Abstract
Group A Streptococcus pyogenes (GAS) exhibits a high degree of clinically relevant phenotypic diversity. Strains vary widely in terms of antibiotic resistance (AbR), clinical severity, and transmission rate. The data show that resistance and virulence are very tightly correlated with the serotype, and that multiple methods of rapidly inferring serotypes are essentially identical in terms of sensitivity and specificity. Recombination, horizontal transfer, and other forms of reassortment are rare in GAS. Therefore, indirect measures such as PCR/ESI-MS offer efficient ways to predict emm type and the associated AbR and virulence phenotypes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 04, 2009
- Accession Number
- ADA515129
Entities
People
- Christian J. Hansen
- Daisy R. Cabrera
- Darcie Baynes
- David Metzgar
- Dennis J. Faix
- Erin A. Mcdonough
- Kevin L. Russell
- Melody M. Ellorin
- Patrick J. Blair
Organizations
- Naval Medical Research Center